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Home page > Thematics > Recoding to study translation > Stop codon readthrough

Stop codon readthrough

For the organisms using a standard genetic code, translation termination occurs when one of the three stop codons, UAA, UGA and UAG, enters the ribosomal A-site. In contrast to the recognition of sense codons by tRNA, stop codons are recognized by extra-ribosomal proteins called class I release factors. The efficiency of translation termination depends on competition between the recognition of the stop codon by a class I release factors, and the decoding of stop codon by a near-cognate tRNAs.

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Schematic of the competition between release factors and near-cognate tRNA.
 [1] Copyrigth 2010, Namy. [1] Translational errors: from yeast to new therapeutic targets. Bidou L, Rousset JP, Namy O. FEMS Yeast Res. 2010. (8):1070-82.




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